A New Scientific Study Has Confirmed That Kratom Has No Measurable Beta-Arrestin Recruitment, And Has Functional Selectivity For G-Protein Signaling, Meaning That Kratom Lacks Physical Addiction Potential And Doesn't Cause Respiratory Suppression
A new scientific study titled ‘Chemical composition and biological effects of kratom (Mitragyna speciosa): In vitro studies with implications for efficacy and drug interactions‘ has just come out, and it has confirmed that Kratom’s primary alkaloids, Mitragynine and 7-hydroxymitragynine, have functional selectivity for G-protein signaling, and have no measurable beta-arrestin recruitment.
Notably, this isn’t the first time that a scientific study has found this result, since The Kratom Herald posted an article about this topic a year ago, but it is certainly important that another study has confirmed this result.
What this result means in simpler terms is that although Kratom’s alkaloids bind to the opioid receptors and provide pain relief, Kratom is completely different, and much safer, than synthetic opioids and opiates.
Basically, synthetic opioids and opiates do recruit beta-arrestin, which suppresses the body’s norepinephrine (adrenaline). This suppression of adrenaline leads to vicious physical withdrawals when the opioids are discontinued, since adrenaline floods through the body.
Additionally, the suppression of adrenaline from beta-arrestin recruitment leads to dangerous and potentially deadly respiratory suppression.
Therefore, since Kratom has no measurable beta-arrestin recruitment, Kratom doesn’t cause respiratory suppression, nor does Kratom cause significant physical addiction.
In-fact, Kratom’s lack of beta-arrestin recruitment is the key to why Kratom is so miraculous. Thanks to functional selectivity for G-protein signaling, Kratom does have all the benefits of opioids such as pain relief and boosting mood, but since Kratom doesn’t recruit beta-arrestin, it doesn’t have the dangerous side effects of synthetic opioids and opiates.
Thus, this scientific study adds to the pile of evidence that Kratom is safe while simultaneously being highly effective. Indeed, the scientists who wrote this study conclude “Overall, the study demonstrates the unique binding and functional profiles of the kratom alkaloids, suggesting potential utility for managing pain, but further studies are needed to follow up on these in vitro findings.”