New Scientific Study Finds That Kratom Does Not Induce Drug Effects Within The Mesolimbic Pathway AKA Reward Pathway, Suggesting Lack Of Addiction Potential
A group of scientists in the Department of Molecular and Cellular Biology at the University of Guelph in Ontario, Canada have conducted an in-depth scientific study of Kratom’s effects within the brain, and one of the most notable conclusions from this study is that Kratom does not induce drug effects within the Mesolimbic Pathway, also known as the reward pathway, and therefore Kratom lacks addiction potential. This corroborates other scientific studies, including a recent study which found that Kratom causes no physiological dependence.
In this scientific study rats were given Mitragynine, which is Kratom’s primary alkaloid, and local field potential recordings of the brain were conducted for 45 minutes after Mitragynine administration. Essentially, local field potentials are a measure of brain activity, and this allows scientists to measure Kratom’s effects on specific parts of the brain.
Specifically, the scientists focused on how Kratom interacts with the prefrontal cortex, cingulate cortex, orbitofrontal cortex, nucleus accumbens, hippocampus, thalamus, basolateral amygdala, and ventral tegmental. Considering this, this experiment is likely one of the most thorough Kratom neuroscience studies to date.
The most notable finding, aside from a general finding that Kratom impacts delta, theta, and gamma waves throughout the brain in various ways, is that Kratom does not cause drug effects in the Mesolimbic Pathway.
The Mesolimbic Pathway is commonly called the reward pathway because the release of dopamine from the Mesolimbic Pathway into the nucleus accumbens regulates the body’s desire and motivation for rewarding stimuli, and facilitates reinforcement and reward related learning. Essentially, all addictions have their roots in the biochemistry that occurs in the Mesolimbic Pathway, including drug addictions.
Indeed, drug addiction is so dangerous because it activates the Mesolimbic Pathway by flooding it with dopamine, making someone feel pleasure and achievement, causing that person to keep taking drugs, and also to neglect regular things that cause pleasure and achievement like working, relationships, and even food and basic hygiene.
Therefore, the fact that Kratom does not cause drug effects within the Mesolimbic Pathway is a major scientific discovery. This means that Kratom doesn’t cause significant addiction, unlike most other psychoactive drugs, and Kratom use does not cause people to neglect the regular things they feel rewards from, like food, family, and working.
In-fact, this seems to be the scientific explanation for the subjective observation that Kratom users are fully functional in both work and relationships, and people who switch from synthetic opioids and opiates to Kratom report that they got their life back.
Thus, this study shows scientifically how Kratom has very little physiological addiction potential, and how Kratom use does not interfere with a person’s responsibilities and life, since Kratom doesn’t short circuit the brain’s reward pathway.