New Scientific Study Finds That Kratom Has No Abuse Potential, Via An Intracranial Self-Stimulation (ICSS) Experiment On Rats
A group of scientists at the University of Florida led by renown Kratom scientist Christopher R. McCurdy have just conducted ground breaking research which has proven that Kratom has no abuse potential in a study titled ‘Evaluation of the rewarding effects of mitragynine and 7-hydroxymitragynine in an intracranial self-stimulation procedure in male and female rats‘.
In this study the intracranial self-stimulation (ICSS) procedure was performed on rats, with ICSS being a widely accepted and accurate way to test the abuse potential of a drug. Essentially, with ICSS a rewarding drug causes a decrease in the brain’s reward thresholds, whereas a non-rewarding drug, i.e. an aversive drug, causes an increase in the brain’s reward thresholds. Basically, a suppressed brain reward threshold corresponds to feelings of being high, which leads to chronic redosing and addiction, whereas an increased brain reward threshold means a drug has little abuse/addiction potential.
As a control in this experiment, some of the rats were given Morphine, and the brain reward threshold decreased, affirming that Morphine is indeed addictive.
However, when the primary Kratom alkaloids Mitragynine and 7-hydroxymitragynine were administered, the brain reward thresholds increased, indicating that Kratom does not cause a ‘drug-like’ reward effect, and therefore Kratom has no abuse potential.
Indeed, the scientists conclude the study by saying “These initial findings indicate that mitragynine and 7-hydroxymitragynine are not rewarding in the ICSS procedure. The present results suggest that these kratom alkaloids do not have abuse potential.”
Further, the ICSS procedure can simultaneously determine the sedative properties of a drug, and this study confirmed that Morphine is extremely sedative, whereas Kratom only causes slight sedation. This is in-line with countless subjective reports that people who use Kratom can still function normally, whereas people on synthetic opioids and opiates are generally dysfunctional, and trapped in a cycle between being too high and not able to function or in withdrawal and not able to function. Indeed, this is why many people have said that Kratom gave their life back.
Zooming out, this is some of the most definitive proof yet that Kratom has little to no addiction and abuse potential. Other scientific studies have confirmed Kratom’s lack of abuse potential in various ways, such as Kratom does not cause drug-like effects in the Mesolimbic Pathway (the reward pathway), and in experiments on rats Kratom caused no increase in re-dosing versus salt water.
Thus the case continues to build that Kratom is a miraculous substance, with incredible benefits but little to no abuse potential.