Scientific Study Finds That Kratom Can Help Mitigate Inflammation Via Inhibiting Nitric Oxide Over-Production
A previous article on The Kratom Herald discussed how Kratom has anti-inflammatory properties similar to Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) like Ibuprofen and Aspirin, and Kratom’s anti-inflammatory properties are from the inhibition of the COX-2 enzyme, which is similar to NSAIDs, except Kratom does not inhibit COX-1, making Kratom much safer since the lack of COX-1 inhibition means Kratom doesn’t cause ulceration in the gastrointestinal tract. Essentially, Kratom has all the anti-inflammatory benefits of NSAIDs without the bad side effects.
Another study titled ‘Chemical constituents and nitric oxide inhibitory activity of supercritical carbon dioxide extracts from Mitragyna speciosa leaves‘ has confirmed that Kratom has anti-inflammatory properties as well, except instead of studying Kratom’s influence on COX enzymes, this study focuses on Kratom’s interaction with nitric oxide.
Essentially, nitric oxide is a key mediator of inflammation in the body, and normally nitric oxide is anti-inflammatory, but certain diseases and conditions cause over-production of nitric oxide, leading to serious inflammation.
In order to analyze Kratom’s effects on nitric oxide various extractions of Kratom were made, including an extract that had zero alkaloids. Interestingly, it was found that a non-alkaloidal extract of Kratom caused the highest inhibition of nitric oxide.
Literally, this experiment found that the non-alkaloidal constituents of Kratom have medicinal properties, and in this case specifically they can inhibit the over-production of nitric oxide, making Kratom a potential cure for diseases and conditions that cause inflammation.
Based on this, the scientists conclude “This study provides first evidence that M5S1, the non-alkaloidal extract obtained by supercritical fluid extraction of M. speciosa leaves possesses potential property in preventing inflammatory diseases mediated by excessive production of NO.”
Thus, this study presents even more evidence that Kratom has highly beneficial anti-inflammatory properties, and not only does Kratom suppress inflammation via inhibiting the COX-2 enzyme, but Kratom also inhibits inflammation via stopping the over-production of nitric oxide.