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Scientific Study Finds That Kratom Completely Eliminates Fever, And Has More Powerful Antipyretic Capabilities Than NSAIDs Like Ketoprofen And Ibuprofen

kratom antipyretic

A peer reviewed scientific study has proven that Kratom has significant antipyretic effects, i.e. Kratom can significantly reduce fever. In-fact, this study found that Kratom is even better at reducing fevers than non-steroidal anti-inflammatory drugs (NSAIDs), such as the commonly used fever reducer Ibuprofen.

The study is from the University Putra Malaysia, and is titled ‘Antipyretic Effect of Mitragynine and Crude Methanolic Extract of Mitragyna speciosa Korth. in Mice‘. Essentially, scientists induced fever in mice by injecting them with yeast, and then the mice were given Ketoprofen, which is an NSAID like Ibuprofen, as well as varying concentrations of Mitragynine and full spectrum Kratom extract.

First off, it was found that Mitragynine, which is Kratom’s primary alkaloid, reduced fever approximately as well as Ketoprofen.

However, the incredible result in this study was that full spectrum Kratom extract, which contains all of the dozens of alkaloids in Kratom, absolutely eliminated the fever. In-fact, the body temperature’s of the mice got so low after a high dose of Kratom that they were technically hypothermic, i.e. the body temperature was lower than the normal body temperature.

The scientists then speculate that the possible mechanism behind Kratom’s antipyretic effects is that Kratom inhibits the cyclooxygenase (COX) enzyme, and the suppression of this enzyme breaks the reaction which causes fevers. This is the same mechanism of action by which NSAIDs reduce fever. Therefore, the scientists are saying that Kratom and NSAIDs reduce fever via the same mechanism, but more experiments are needed to confirm this.

Zooming out to subjective data, I have noticed that whenever I have been sick that a sizable dose of Kratom knocks out practically all symptoms including fever, and I have read similar subjective reports from Kratom users across the internet.

Thus, it has been scientifically confirmed that Kratom is better for reducing fevers than NSAIDs like Advil and Ibuprofen. In-fact, NSAIDs only partially reduce fever, while Kratom actually completely knocks out the fever.