Scientific Study Suggests That Kratom Can Suppress Hallucinations And Has Anti-Psychotic Properties, Via Antagonism At the Serotonin Receptors And Adrenoceptors
Scientists conducted an ingenious experiment where they injected mice with DMT and Kratom, and ultimately determined that Kratom has anti-hallucinogenic properties, in a scientific study titled ‘Suppressive effect of mitragynine on the 5-methoxy-N,N-dimethyltryptamine-induced head-twitch response in mice‘.
Specifically, the scientists injected mice with 5-MEO-DMT, which is basically the same thing as DMT, and is a widely popular hallucinogen. The reason the scientists did this was in order to induce hallucinations in the mice, and after that point the scientists could see if Kratom was able to inhibit those hallucinations.
Notably, it is difficult to measure hallucinations directly, but apparently head twitches in mice are directly correlated with hallucinations, so the scientists were able to measure the hallucinations via measuring head twitches.
It was found that Mitragynine, Kratom’s primary alkaloid, significantly suppressed the DMT induced head twitches in the mice, which means Kratom reduced the DMT induced hallucinations, and therefore Kratom has anti-hallucinogenic effects in general.
The scientists then dived into the science as to why this is the case, and speculate that Kratom has anti-hallucinogenic properties via antagonism, i.e. blocking, the postsynaptic adrenoceptors (adrenaline), the 5-HT2A (Serotonin) receptors, or both. The scientists then go on to speculate that Mitragynine may directly blockade the Serotonin receptors, or modulate the Serotonin receptors via it’s interaction with the adrenoceptors.
The science is complex, but what this essentially boils down to is that Kratom likely has anti-hallucinogenic properties, via suppressing the Serotonin receptors which are responsible for hallucinations.
The scientists conclude “It can be speculated that Mitragynine may suppress the occurrence of hallucinations triggered by stimulation of The 5-HT2A receptor-mediated head-twitch response in humans.”
This is a critical result, since it suggests that Kratom could be used as an anti-psychotic. This is a big deal, since the anti-psychotic medicines which exist now are not very effective, and also have so many complex interactions with the brain that they cause all sorts of negative side-effects, whereas Kratom has little, if any, negative side-effects.
Essentially, if Kratom really can be used as an anti-psychotic, which is something that needs to be determined through further research, it would be really good for the world since Kratom would provide anti-psychotic benefits with little to no side effects, whereas the currently used anti-psychotic medications have terrible side effects.