7-Hydroxymitragynine Levels In Kratom Powder Are 100%-500% Higher Than The Levels In Natural Leaf, Since 7-hydroxymitragynine Is Apparently Not Produced Within Kratom Leaves, But Rather Forms Via The Oxidation Of Mitragynine After Harvesting
Mitragynine and 7-hydroxymitragynine are considered the primary Kratom alkaloids, and in-fact most Kratom laboratories only test for those two alkaloids when assessing the potency of Kratom Powder.
Notably, while Mitragynine is by far the most abundant alkaloid, 7-hydroxymitragynine is over 20 times stronger than Mitragynine in terms of analgesic (pain relieving) effects, and therefore the levels of 7-hydroxymitragynine in Kratom Powder are considered critically important for gauging the analgesic properties of a certain Kratom strain.
All of that being said, according to a new scientific study from Christopher R. McCurdy, who is a world famous Kratom scientist, 7-hydroxymitragynine is apparently not even naturally produced in Kratom. Rather, 7-hydroxymitragynine is produced by an oxidative process after harvesting.
Indeed, fresh Kratom leaves from Malaysia were tested, and the levels of 7-hydroxymitragynine were below the quantifiable limit of 0.01%. However, 7-hydroxymitragynine levels in Kratom Powder in the United States are commonly well above 0.01%, and as high as 0.05%.
In-fact, Kratom Powder in the United States was found to have 7-hydroxymitragynine levels 109%-520% higher than Kratom preparations in native settings.
The explanation for this is that 7-hydroxymitragynine in Kratom only begins to develop after harvesting via an oxidative process, where Mitragynine transforms into 7-hydroxymitragynine.
Specifically, Kratom growers commonly put fresh Kratom leaves into bags of water and leave them out in the sun, and this fermentation leads to oxidation of Mitragynine, which in turn leads to increasing concentrations of 7-hydroxymitragynine. Indeed, Red Vein Kratom, which is well-known as being more analgesic, is created via this process.
The scientific study concisely sums this up: “According to our experience with freshly prepared kratom samples, 7-hydroxymitragynine is not produced by the plant but rather, oxidation of mitragynine occurs post-harvest during the drying, transportation, and/or manufacturing processes.”
Thus, although 7-hydroxymitragynine is considered one of the most important Kratom alkaloids, it is barely produced within natural Kratom leaves, if at all. Rather, specialized fermentation and drying processes lead to the formation of 7-hydroxymitragynine via oxidation of Mitragynine, and this explains why Kratom powder has 7-hydroxymitragynine levels hundreds of percent higher than fresh leaf.
In conclusion, the Kratom powder we know and love has much stronger analgesic properties than natural Kratom leaf, thanks to techniques which drastically increase the levels of the potent alkaloid 7-hydroxymitragynine post-harvesting.