Kratom Fundamentally Lacks Abuse Potential Since Kratom Is Only Effective Orally, And Not Effective Intravenously Or Intranasally, Since Kratom's Effects Are Dependent On Conversion Of Mitragynine Into 7-hydroxymitragynine In The Liver
One of the things that makes synthetic opioids and opiates so dangerous is that they can be easily used via intranasal use (snorting) or intravenous use, allowing a user to put a massive dose of the drug into the bloodstream within seconds. This drastically increases the abuse and addiction potential of opioids, and also the danger.
On the other hand, one of the things that makes Kratom fundamentally safe is it is not effective intransally or intravenously, rather Kratom is only effective orally, and this has been proven by science.
The below chart, which was obtained from Dr. Andrew Kruegel who presented this information at the American Kratom Association (AKA) Kratom Leadership Summit, shows the analgesic effectiveness of Kratom’s primary alkaloid Mitragynine when it is injected under the skin (subcutaneous, s.c. in the chart), and when it is taken orally (p.o.) in the chart.
What this chart shows is that orders of magnitudes more Mitragynine is needed in order to produce an equivalent analgesic effect when Mitragynine is injected under the skin. In other words, injecting Mitragynine is orders of magnitude less potent than simply taking Mitragynine orally.
As Dr. Kruegel explained in his presentation, the reason for this is that while Mitragynine is the primary alkaloid in Kratom, most of Kratom’s analgesic effects are actually due to the conversion of Mitragynine into 7-hydroxymitragynine via the CYP3A4 enzyme in the liver.
Putting all of this together, Kratom’s opioid analgesic effects are primarily due to Mitragynine metabolizing into 7-hydroxymitragynine in the liver, and this metabolic process can only happen if Kratom is taken orally.
If Kratom is taken intranasally or intravenously, then it goes directly into the bloodstream and doesn’t pass through the liver, and therefore the Mitragynine in the Kratom does not metabolize into 7-hydroxymitragynine, leading to opioid analgesic effects that are orders of magnitudes weaker.
Essentially, Kratom cannot be snorted or injected to achieve a rapid opioid high, since Kratom must pass through the liver and metabolize into 7-hydroxymitragynine in order to have strong opioid analgesic effects, and this can only occur if Kratom is taken orally.
Thus, Kratom has a built-in mechanism to prevent abuse, since it is not effective when injected or snorted, and this is true regardless of how pure an extract is. Even a 100% pure Mitragynine extract is still only effective when taken orally.