The Kratom Herald

Mitragyna Speciosa News And Information

New Scientific Study Indicates That Kratom's Most Potent Alkaloid, 7-Hydroxymitragynine, Is Safe Even In Very High Doses

The University of Florida, which is one of the biggest hotspots for Kratom Science, has just released a new scientific study titled “Oral Pharmacokinetics in Beagle Dogs of the Mitragynine Metabolite, 7-Hydroxymitragynine“.

Essentially, 7-hydroxymitragynine is the most potent alkaloid in Kratom, since it is a powerful full mu-opioid agonist, unlike Mitragynine which is a weak partial mu-opioid agonist. Simultaneously, there have been numerous scientific studies which have proven the safety and efficacy of Mitragynine (Kratom’s primary alkaloid), but there have been very few scientific studies which have proven the safety of 7-hydroxymitragynine.

Therefore, this new scientific study from the University of Florida sought to determine if 7-hydroxymitragynine is safe or not. In order to do this pure 7-hydroxymitragynine was given to dogs, comparable to how the pharmaceutical industry commonly tests drugs/substances on animals instead of humans in the early stages of clinical trials.

Ultimately, this scientific study found that even very high doses of 7-hydroxymitragynine were well-tolerated by the dogs, and in-fact there were zero adverse effects.

This is a major result considering the dogs received 1 mg/kg of 7-hydroxymitragynine. In comparison, even the strongest Kratom contains just 0.05% 7-hydroxymitragynine. Based on that, a heavy 10 gram serving of Kratom contains just 5 mg of 7-hydroxymitragynine, and therefore a 100 kg human would have to take 200 grams of highly potent Kratom to achieve 1 mg/kg of 7-hydroxymitragynine.

Thus, even when the dogs received doses of 7-hydroxymitragynine far higher than what a human takes, the dogs still had zero adverse reactions.

All things considered, this data strongly indicates that 7-hydroxymitragynine is extremely safe, and therefore this data shoots down all speculation that 7-hydroxymitragynine is dangerous due to its full opioid agonist characteristics. 

Of course, more scientific studies need to be conducted to definitively confirm this, especially human studies need to be done, although based on this scientific data and countless subjective reports of Kratom use, it is pretty clear that 7-hydroxymitragynine, and all the other alkaloids in Kratom, are safe.