Scientific Study Finds That The Kratom Alkaloid Corynoxine Is A Potent Mu-Opioid Agonist, And Therefore Plays An Important Role In Kratom's Effects
It is well-known that the primary Kratom alkaloids Mitragynine and 7-hydroxymitragynine have potent opioid effects, and it is generally believed that most of Kratom’s painkilling and euphoric effects are due to the opioid action of Mitragynine and 7-hydroxymitragynine.
However a new scientific study has found that there is another potent opioid alkaloid in Kratom. The scientific study is titled “Exploring the Chemistry of Alkaloids from Malaysian Mitragyna speciosa (Kratom) and the Role of Oxindoles on Human Opioid Receptors“.
Specifically, this study found that the Kratom alkaloid Corynoxine is a potent mu-opioid agonist. In-fact, an experiment was conducted on rats and Corynoxine was determined to be 1.8 times more potent than Morphine in terms of analgesic painkilling effects.
This actually makes Corynoxine a far more potent opioid alkaloid than Mitragynine, since Mitragynine has analgesic effects only roughly half as strong as Morphine. On the other hand, 7-hydroxymitragynine is still by far the most potent opioid alkaloid in Kratom, with analgesic effects that are over 10X stronger than Morphine.
Zooming out, the main takeaway from this new finding is that Corynoxine likely plays an important role in Kratom’s overall pain relieving, stress relieving, and euphoric effects, and more research into Corynoxine is needed.
Further, Kratom has over 50 alkaloids, and it is likely that many of the other lesser-known Kratom alkaloids have opioid effects besides Mitragynine, 7-hydroxymitragynine, and Corynoxine, it’s just that more research needs to be done on each alkaloid in order to understand them.
On a final note, the fact that Corynoxine has strong opioid effects is yet another reason to take natural Kratom powder instead of Kratom extracts, since Kratom extracts typically only contain Mitragynine, and the only way to get the full benefits of Kratom and all of its alkaloids is to take Kratom leaf/powder.