Scientists Are Developing Kratom-Based Drugs Which Are Effective For Combatting Alcoholism, And Have Determined That Kratom Reduces Alcohol Consumption Via Interacting With The Delta-Opioid Receptor
It is well-known and well-proven that Kratom is effective for combatting alcoholism. Indeed, the article at this link discusses scientific studies which prove that Kratom literally eliminates the pleasure from Alcohol, via inhibiting the release of dopamine when alcohol is ingested, causing people to stop drinking. Additionally, that article includes my personal story about how Kratom defeated my alcoholism. I was drinking 10-20 drinks every night of the week, but once I started using Kratom I literally lost all my desire to drink alcohol, despite the fact I wasn’t even trying to quit drinking. Beyond that, you can find several real-life accounts at this link about how Kratom has saved people from alcoholism.
Now a new study has come out which describes how scientists are developing synthetic Kratom-based drugs which can combat alcoholism. The study is titled ‘Pharmacological Characterization of Synthetic Kratom Alkaloids for Improved Alcohol Use Disorder Therapeutics‘.
Essentially, the scientists in this study recognize that natural Kratom is an effective way to combat alcoholism, but the scientists believe that Kratom is too rewarding, and therefore they are synthesizing synthetic Kratom-based alkaloids that combat alcohol while providing less pleasure.
More specifically, these scientists aimed to produce Kratom analogs which don’t bind to the mu-opioid receptor, while simultaneously binding to the delta-opioid receptor, since the mu-opioid receptor is responsible for much of Kratom’s pleasurable effects, and the delta-opioid receptor is apparently responsible for Kratom’s anti-Alcohol effects.
The scientists succeeded in their mission, and they created a synthetic Kratom analog that has very little affinity for the mu-opioid receptor. The scientists tested this synthetic alkaloid on alcoholic mice, and found that it significantly reduced their alcohol consumption.
Ultimately, the main takeaway from this study is that Kratom’s interaction with delta-opioid receptors is the main reason why Kratom combats alcoholism, which is something that was perhaps not well understood before this study.
Indeed, the scientists conclude “Our results indicate that the development of potent, DOR-selective opioids could provide a pathway to treat alcohol use without being significantly rewarding, and that the kratom alkaloids provide useful scaffolds to jumpstart these efforts.”.
That being said, I disagree that it is necessary to produce a synthetic Kratom analog that does not bind to the mu-opioid receptors. Kratom’s affinity for the mu-opioid receptors is why Kratom causes happiness, relieves pain, and lifts depression, all of which are very helpful things for helping someone quit alcohol.
Therefore, I argue that natural Kratom is superior for combatting alcoholism versus the synthetic Kratom alkaloids these scientists are creating, and therefore synthetic Kratom-based anti-alcohol drugs are unnecessary.
However, this scientific study is still quite good, since it highlights how Kratom is effective for combatting alcoholism, and this study has also determined the specific mechanism by which Kratom reduces alcohol consumption, which is via binding with the delta-opioid receptor.