Scientists Discover That 7-Hydroxymitragynine Transforms Into A Much More Powerful Compound, Mitragynine Pseudoindoxyl, Inside The Body, And This May Explain Most Of Kratom's Effects
A group of scientists at the University of Florida, led by renown Kratom scientist Christopher R. McCurdy, have published a groundbreaking study titled ‘Metabolism of a Kratom Alkaloid Metabolite in Human Plasma Increases Its Opioid Potency and Efficacy‘.
Essentially, it has been discovered that 7-hydroxymitragynine, a primary Kratom alkaloid, is converted into Mitragynine Pseudoindoxyl in human blood.
It is well known that 7-hydroxymitragynine is far more potent than Mitragynine, and likewise Mitragynine Pseudoindoxyl is far more potent than 7-hydroxymitragynine. Specifically, a scientific study found that the effective concentration of Mitragynine Pseudoindoxyl at the mu-opioid receptor is 100 times less than Mitragynine and 20 times less than Morphine, which translates to Mitragynine Pseudoindoxyl being 20 times more potent than Morphine and 100 times more potent than Mitragynine.
Another way to look at it is that the dissociation constant of Mitragynine, 7-hydroxymitragynine, and Mitragynine Pseudoindoxyl at the mu-opioid receptor is 230, 37, and 0.8 respectively. A smaller dissociation constant equals a higher binding affinity for the mu-opioid receptor, and therefore Mitragynine Pseudoindoxyl is in a league of its own in terms of how well it binds to the mu-opioid receptor relative to the other primary Kratom alkaloids.
Ultimately, the scientists who wrote this study conclude “Due to its μ-opioid potency Mitragynine Pseudoindoxyl may substantially contribute to the pharmacology of kratom in humans”.
Notably, this transformation of 7-hydroxymitragynine into Mitragynine Pseudoindoxyl only occurs in human blood, and that’s why animal experiments did not pick up on this before.
Taking this theory a step further, it has already been discovered that Mitragynine is converted into 7-hydroxymitragynine by the liver. Therefore, although by far the most abundant alkaloid in Kratom is Mitragynine, Kratom’s effects are largely due to Mitragynine being converted into 7-hydroxymitragynine in the liver, and then that 7-hydroxymitragynine is converted into Mitragynine Pseudoindoxyl in the blood.
Essentially, the human body converts Mitragynine into much stronger opioid compounds. Another way to say it is that Kratom becomes much more powerful and effective due to the chemistry which occurs in the body.
On a final note, the fact that this major breakthrough is just being discovered now shows how we are still in the early years of Kratom science, and there are undoubtedly many more incredible things about Kratom that will be discovered in the coming years.